![]() ![]() The entire autumn crocus plant is toxic, primarily due to colchicine content. Information regarding safety and efficacy in pregnancy and lactation is contradictory. ContraindicationsĬontraindications have not been identified. The main component colchicine has a narrow therapeutic index use of colchicine (whether from a plant-based extract or a purified form) requires medical supervision. Dosingĭata are lacking to provide dosing recommendations for any indication. However, the plant is considered toxic and no clinical trials are available to support the use of autumn crocus for any indication. Autumn crocus may have benefit in conditions such as cirrhosis or hyperthyroidism. Clinical Overview Useĭue to its main active constituent colchicine, autumn crocus plant and its extracts have traditionally been used to treat gout and related inflammatory disorders. Ker-Gawl, Colchicum autumnale L., Colchicum speciosum StevenĬommon Name(s): Autumn crocus, Crocus, Fall crocus, Gowri gedde, Meadow saffron, Mysteria, Naked lady, Vellorita, Wild saffron, Wonder bulb New maps and improved taxonomy were generated by Elizabeth D.Scientific Name(s): Bulbocodium vernum L. The Project was originally started by Dr. Colorado State University web pages do not endorse any commercial providers or their products. Nor does Colorado State University warrant that the use of this information is free of any claims of copyright infringement. © 2022 - Guide to Poisonous Plants | The information contained herein is provided as a public service with the understanding that Colorado State University makes no warranties, either expressed or implied, concerning the accuracy, completeness, reliability, or suitability of the information. Mendis S: Colchicine cardiotoxicity following ingestion of Gloriosa superba tubers. et al: Accidental poisoning with autumn crocus. The stamens of Crocus sativus flowers are the source of saffron, an expensive food coloring and spice.Īnimals or people who are known to have eaten any part of the bulb, flowers or seeds of the autumn crocus should be seen by a veterinarian or physician, as appropriate, as quickly as possible.ġ.Yamada AM et al: Histological study of experimental acute poisoning of cattle by autumn crocus (Colchicum autumnale). This should not be mistaken for Crocus sativus, a member of the Iridaceae family, that also flowers in the autumn. ![]() The best known species of the genus is Colchicum automnale, called autumn crocus as it is an autumn flowering species. Maintain kidney function with intravenous fluid therapy and other supportive therapy as necessary.Ĭolchicine can be detected in the serum and urine. Severe salivation, vomiting, abdominal pain and severe hemorrhagic diarrhea. Many species tend to flower in the fall, but others may flower in the spring. In contrast to Crocus species, which have 3 stamens, Colchicum flowers each have 6 stamens and three pistils. Flowers are produced singularly or clusters atop long tubes and are generally purple, pink, or white in color. The leaves are basal, long, linear blades. ![]() Arising from corms, almost all species produce flowers before they produce leaves. Many species originate from the Mediterranean area around Turkey and the Balkans. An estimated lethal dose of colchicine is 0.8 mg per kilogram body weight.Īnother plant that is known to contain colchicine and similar alkaloids is the Glory Lilly (Gloriosa superba) which contains up to 0.36% colchicine in its tubers.Ĭomprising the genus of some 60 species originating in Europe and North America and West and Central Asia. Colchicine also causes marked decreases in prolactin, insulin, glucose tolerance, and catecholamine production. Multiple organ failure is characteristic of acute colchicine poisoning. Colchicine and its related alkaloids interfere with microtubular dependent cell function's by binding to tubulin protein, thus blocking mitosis in multiple tissues.1 All animals are susceptible to the toxic effects of colchicine. The primary toxic alkaloid is colchicine, which interferes with cell mitosis. However, the corms are large enough to contain toxic doses of the alkaloids. The corm is also toxic containing 0.05% alkaloids, in contrast to 0.2% in the seeds. All parts of autumn crocuses are poisonous, the greatest concentrations of toxic alkaloids occurring in the flowers and seeds. ![]()
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